By 9.5 mo of age, mice (PS19) develop strong tau hyperphosphorylation and aggregation, neurofibrillary tangle deposition, gliosis, neuronal loss, brain atrophy, and loss of synaptic proteins in specific brain regions including the hippocampus, entorhinal cortex, piriform cortex, and amygdala (Yoshiyama et al, 2007). Here, MAPT is linked to Brain atrophy.