Interestingly, we identified an alternative 3’ss (HsaALTA1027057-2/4 in VastDB) in the MAP3K7 gene itself displaying strong mis-regulation upon SF3F1 mutation (ΔPSI = 60 in SF3B1WT versus SF3B1K700E CLL patients’ samples and ΔPSI = 70 in SF3B1WT versus SF3B1K700E MEC1 CLL cell lines). Here, MAP3K7 is linked to B-cell chronic lymphocytic leukemia.