Enrichment of differential gene expression and differentially spliced events between SF3B1WT and SF3B1K700E MEC1 CLL cell lines showed a significant enrichment of genes involved in I-κB kinase/NF-κB signaling and its regulation (GO:0043122, GO:0007249) (Fig 5C). The gene discussed is NFKB1; the disease is B-cell chronic lymphocytic leukemia.