SF3B1 and B-cell chronic lymphocytic leukemia: SF3B1-binding splicing modulators, such as spliceostatin A, sudemycins and pladienolide B and its derivative FD-895, have shown stronger cytotoxic effects on CLL samples than on normal B lymphocytes (Kashyap et al, 2015; Xargay-Torrent et al, 2015; Larrayoz et al, 2016).