SF3B1 and B-cell chronic lymphocytic leukemia: Another reported mechanism involves activation of an Alt3’ss in PPP2R5A, a protein phosphatase 2A subunit that promotes MYC stability and impairs apoptosis by increasing MYC S62 and BCL2 S70 phosphorylation in SF3B1-mutated tumors, including CLL (Liu et al, 2020).