Other AS events that may confer advantages to SF3B1-mutated CLL cells have been described, including an Alt3’ss in DVL2, a gene that negatively regulates Notch pathway (Collu et al, 2012) and which has been linked to Notch1 activation in SF3B1-mutated CLL (Wang et al, 2016; Pozzo et al, 2020). Here, NOTCH1 is linked to B-cell chronic lymphocytic leukemia.