Despite these noted limitations, our screen uncovered many genes that are known to regulate steps of melanosome maturation and whose functional loss leads to oculocutaneous albinisms (OCAs) and ocular albinism (OA) syndromes in humans, such as TYR (OCA1), OCA2, SLC45A2 (OCA4), SLC24A5 (OCA6), LRMDA (OCA7), DCT (OCA8), and GPR143 (OA). This evidence concerns the gene DCT and oculocutaneous albinism.