Loss of ALOX12B, in particular, has been associated with autosomal recessive congenital ichthyosis (ARCI) (44), a group of inherited dermatologic diseases characterized by skin scaling and epidermal barrier defects due to defective keratinocyte maturation (43, 45), which shares clinical features with DD, including response to retinoid therapy (17). This evidence concerns the gene ALOX12B and dentin dysplasia.