ATP2A2 and dentin dysplasia: Mutation of the ATP2A2 gene, which encodes sarco-endoplasmic reticulum calcium ATPase 2 (SERCA2), causes Darier disease (DD) (6, 7), a dermatologic disorder characterized by aberrant epidermal differentiation and impaired keratinocyte adhesion via desmosomes (8, 9), which manifests as recurrent skin blisters, erosions, and infections (10–13).