ATP2A2 and dentin dysplasia: Since KRT10 is a major regulator of epidermal integrity and differentiation (47–49), a concomitant reduction of KRT10 in SERCA2-depleted epidermis could be responsible for the impaired intercellular adhesion and abnormal cornification seen in HET organotypic epidermis, which overlap with the pathologic features seen in DD biopsies.