Since KRT10 is a major regulator of epidermal integrity and differentiation (47–49), a concomitant reduction of KRT10 in SERCA2-depleted epidermis could be responsible for the impaired intercellular adhesion and abnormal cornification seen in HET organotypic epidermis, which overlap with the pathologic features seen in DD biopsies. The gene discussed is KRT10; the disease is dentin dysplasia.