Mutation of the ATP2A2 gene, which encodes sarco-endoplasmic reticulum calcium ATPase 2 (SERCA2), causes Darier disease (DD) (6, 7), a dermatologic disorder characterized by aberrant epidermal differentiation and impaired keratinocyte adhesion via desmosomes (8, 9), which manifests as recurrent skin blisters, erosions, and infections (10–13). Here, ATP2A2 is linked to Darier disease.