T subsets, especially CD4+ CTL, CD8+ CTL-GNLY, CD8+ CTL-GZMK, MAIT, γδT, and proliferating lymphocytes have high chemotaxis scores; IgG4-RD had a significantly higher chemotaxis score and enhanced expression of related genes than HCs, suggesting T cells in PB of IgG4-RD patients receive stronger migration signals (Figure 3, H and I, and Supplemental Figure 4A). Here, GZMK is linked to immunoglobulin G4-related sclerosing disease.