It was observed that the expressions of CASP9, CASP6, CASP8, CASP5, CASP3, CASP4, CASP1, GSDME, GSDMB, GSDMA, GSDMD, GSDMC, IL18, IL1B, NLRC4, NLRP7, NLRP3, NLRP2, NLRP1, NOD1, SCAF11, PRKACA, PYCARD, and PLCG1 were increased, whereas the expressions of ELANE, IL6, NLRP6, TNF, and GPX4 were decreased in ESCC compared to that in normal tissues. The gene discussed is GSDMD; the disease is esophageal squamous cell carcinoma.