To conclude, the current research revealed the protective power of Hmgcs2 against septic myocardial injury, by stimulating macrophage M2 polarization to diminish inflammation induced by sepsis and decreasing cardiomyocyte apoptosis to lessen myocardial injury through the activation of the Src/PI3K/Akt pathway (Supplementary Figure 1). Here, AKT1 is linked to Sepsis.