ZO-1 cells were continuously expressed in the colon of normal mice, and the intestinal mucosal integrity of PD mice was destroyed, and ZO-1 expression significantly lowered (P < 0.001, vs. Normal), its expression raised significantly after CDG therapy (P < 0.001, vs. MP TP; Fig. 6C and F). The gene discussed is TJP1; the disease is Parkinson disease.