Findings revealed that TLR4 expression, TBK1, NF- κB p65, and TNF-α proteins increased significantly in the striatum of PD mice (P < 0.001, P < 0.001, P < 0.001, P < 0.001, vs. Normal), and the above indices were all significantly decreased with CDG therapy (P < 0.05, P < 0.05, P < 0.001, P < 0.001, vs. Here, TLR4 is linked to Parkinson disease.