Gsk3b destabilizes the molecular clock by promoting Bmal1 ubiquitination and subsequent degradation [64, 65], and increased Gsk3b activity has been described in several psychiatric disorders with documented impairment in circadian clock function (e.g. bipolar disorder, schizophrenia, ADHD, and depression) [66]. The gene discussed is CLOCK; the disease is attention deficit-hyperactivity disorder.