Cell-intrinsic inflammatory signaling was initially reported to increase the immunogenicity of tumors with CIN via cGAS/STING-mediated activation of the type I IFN response followed by STAT1 signaling, thereby driving immune infiltration (Tripathi et al. 2019; Schubert et al. 2021). Here, STING1 is linked to cervical squamous intraepithelial neoplasia.