In alignment with this tumor suppressive role of STAT1, an in vivo genome-wide transposon mutagenesis screen revealed that specifically tumors that display CIN inactivate inflammatory signaling through STAT1 inactivation in combination with increased c-Myc activity compared to euploid tumors (Schubert et al. 2021). The gene discussed is STAT1; the disease is cervical squamous intraepithelial neoplasia.