A decrease or loss of STAT1 activity has been reported for many cancer types (Meissl et al. 2017), including tumors with CIN (Schubert et al. 2021), and high STAT1 expression levels correlate with better clinical outcomes (Chen et al. 2013; Gordziel et al. 2013). This evidence concerns the gene STAT1 and cervical squamous intraepithelial neoplasia.