The mouse homolog of the FLT1 gene was amongst a number of genes differentially expressed in calorically restricted mice.27 In our cross-sectional study we found that FLT1 was a longevity gene.28 In the longitudinal study of aging and longevity described above we found an association of the major allele of FLT1 with protection against the risk of mortality posed by hypertension.54 The gene discussed is FLT1; the disease is hypertensive disorder.