HTT and Huntington disease: Therefore, FOXO proteins are considered as metabolic master regulators that control the response to nutrient availability.19 FOXO proteins play critical roles in dementia as they are responsible for the maintenance of quiescence of neuronal stem cells and the clearance of reactive oxygen species (ROS).20 In a cellular model of Huntington disease, the co-expression of wild-type FOXO1 with mutant huntingtin protein promoted autophagy and clearance of the aberrant protein.21 Additionally, levels of nuclear FOXO3 were found to be increased in cells homozygous for Huntington disease mutation.20