DC‐secreted exosomes possess MHC class I or MHC class II peptide complexes, costimulatory molecules (e.g., CD40, CD80, and CD86), tumor necrosis factor (TNF) superfamily ligands (e.g., TNF, FasL, and TRAIL), and NK group 2, member D (NKG2D) ligands (e.g., UL16 binding protein 1) that facilitate antigen presentation and promote the activation of tumor‐specific CTLs.152, 153, 154. Here, TNF is linked to neoplasm.