STING1 and cancer: By discussing the application and potential of lipid‐NPs for STING agonists, we summarized the future perspectives focused on the following points to further promote the application of lipid‐NPs in cancer immunotherapy: (1) in certain instances, lipid‐NPs may trigger an inflammatory response, particularly when CLDs interact with serum proteins and the degradation of biomaterials like LPHNPs.