IRF3 and neoplasm: Moreover, the activation of STING signaling is reported to be involved in the induction of tumor cell apoptosis through the IRF3–BCL2‐associated X protein/BCL2‐antagonist/killer 1 pathway and necroptosis by triggering the expression or phosphorylation of mixed‐lineage kinase domain‐like pseudokinase, one of the major regulators of necrosome formation during necroptotic cell death.263, 264