Moreover, the activation of STING signaling is reported to be involved in the induction of tumor cell apoptosis through the IRF3–BCL2‐associated X protein/BCL2‐antagonist/killer 1 pathway and necroptosis by triggering the expression or phosphorylation of mixed‐lineage kinase domain‐like pseudokinase, one of the major regulators of necrosome formation during necroptotic cell death.263, 264. The gene discussed is STING1; the disease is neoplasm.