PRKAG2 and cardiomyopathy: Heart organoids have been used to explore the connections between metabolism and transcription regulation in protein kinase adenosine monophosphate-activated non-catalytic subunit gamma 2 (PRKAG2) cardiomyopathy caused by missense mutations in the PRKAG2 regulatory subunit (Ntusi et al., 2016; Manhas et al., 2022; Novelli et al., 2022; Vuckovic et al., 2022).