Maternal immune activation was shown to result in anxiety- and depression-like behaviors, cognitive impairment, and increased levels of proinflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha (TNF-α) in offspring (Rahimi et al., 2020; Zhang Z. et al., 2022). This evidence concerns the gene IL1B and major depressive disorder.