The same principle of reducing infection without impacting function should be applied not only to host receptors such as ACE2, but also other cofactors such as NRP1 (Cantuti-Castelvetri et al., 2020; Daly et al., 2020) because a proper level of NRP1 protein is essential for cardiovascular and neuronal development (Guo and Vander Kooi, 2015). Here, ACE2 is linked to infection.