Gallic acid and Caffeic acid block the processes of angiogenesis and tumor growth via protection of the tumoricidal efficacy of M1 macrophages and inhibition of proangiogenic factors, particularly VEGF, MMP-2/9, and cyclooxygenase-2 (COX-2) activity (Orsolic et al., 2020). The gene discussed is MMP2; the disease is neoplasm.