Moreover, earlier reports suggests that co-administration of oxymatrine with doxorubicin produces a better anti-colon cancer effect via enhancing apoptotic signals (cleaved caspase-3, cleaved caspase-9 and Bax/Bcl-2 ratio) in HT-29 and SW620 cells mediated by ROS generation. Here, CASP3 is linked to malignant colon neoplasm.