IGF1 and malignant colon neoplasm: Growing evidence also suggests that mutations in the growth factors such as insulin-like growth factor 1 (IGF-1) also shows a massive impact on the development of colon cancer via activating rat sarcoma/mitogen-activated protein kinase/phosphatidylinositol-3 kinase/protein kinase B (RAS/MAPK/PI3K/AKT) pathways (4, 9).