TP53 and malignant colon neoplasm: Furthermore, capsaicin in combination with 3,3′- diindolylmethane enhances the anti-cancer potential by inducing apoptosis in colon cancer cells like HCT116, SW480, LoVo, Caco-2, and HT-29 via targeting apoptotic markers like Fas, NF-κB, p53 and other proteins (128).