POMC and neoplasm: In the multivariable logistic regression model adjusted for age and gender, we found tumor diameter (per 1-cm increase, OR 1.857 (1.357-2.540), P<0.001) was negatively associated and plasma ACTH was positively associated with decreased DHEAS, with OR (per 1-unit increase, 0.978 (0.962-0.993), P=0.006) (Table 2).