LDLR and fibrosis: In addition, since Ldlr-/- mice display a human-like lipid profile with significant LDL-C in circulation compared to C57Bl/6J mice, our current data showing the development of ethanol-induced fibrosis in Ldlr-/- mice in the chronic-binge ethanol feeding provide evidence for a novel murine model for studying alcohol-associated liver disease (18).