KLF6 and pachyonychia congenita: In addition, oncogenic miR-125a, miR-10a-5p and miR-342-3p have also been found to enhance GEM resistance of PC cells through targeting A20, transcription factor activating protein 2 gamma (TFAP2C) and Krüppel-like factor 6 (KLF6), respectively (Yao et al., 2016; Xiong et al., 2018; Ma et al., 2019).