AKT1 and pachyonychia congenita: Multiple tumor suppressor miRNAs, such as miR-145, miR-429, miR-30a and miR-760, could also reverse GEM resistance of PC through inhibiting expression of p70S6K1, PDCD4, SNAI1/IRS1/ERK/AKT, moloney leukemia virus 10 (MOV10) and Integrin β1 (ITGB1), respectively (Lin et al., 2016; Yu et al., 2017; Wang T et al., 2019; Yang et al., 2019).