It has been found that tumor suppressor miR-410-3p and miR-29c could attenuate the resistance to GEM in PC through inhibiting expression of High mobility group box 1 (HMGB1) and ubiquitin specific peptidase-22 (USP22) and, thus, reducing autophagy, respectively (Xiong et al., 2017; Huang et al., 2018). This evidence concerns the gene USP22 and pachyonychia congenita.