For instance, tumor suppressors miR-509-5p and miR-1243 have been found to enhance GEM sensitivity through modulating expression of EMT markers E-cadherin, Z O -1, Zinc finger E-box binding homeobox transcription factor 1 (ZEB1) and Snail in PC (Hiramoto et al., 2017). This evidence concerns the gene CDH1 and neoplasm.