TP53 and neoplasm: In human MiaPaCa2 and BxPC3 PC cells harboring P53 mutations, exogenous expression of tumor suppressor miR-34 could not only result in cell cycle arrest, apoptosis, the reduced tumor-initiating cell population and tumor sphere growth, but also sensitize the cells to DDP through down-regulating Notch1/2 and Bcl-2 expression (Ji et al., 2009).