Multiple oncogenic lncRNAs have been shown to contribute to GEM resistance in PC, such as HOXA transcript at the distal tip (HOTTIP), glutathione S-transferase mu 3, transcript variant 2 (GSTM3TV2), metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), plasmacytoma variant translocation 1 (PVT1) and DiGeorge syndrome critical region gene 5 (DGCR5). This evidence concerns the gene GSTM3 and pachyonychia congenita.