It has been found that extracellular vesicle -loaded oncogenic lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) from adipose-derived MSCs could promote GEM resistance in PC by regulating the miR-491-5p/snail/suppressor of cytokine signaling 3 (SOCS3) signaling pathway (Wu et al., 2023). This evidence concerns the gene SOCS3 and pachyonychia congenita.