LINC00460, a lncRNA molecule mainly located in the cytoplasm, has been shown not only to correlate with GEM response in PDAC patients, but also to regulate GEM resistance of CAFs through mediating the cellular communication of PDAC cancer cells and CAFs by platelet derived growth factor subunit A (PDGFA) associated protein 1 (PDAP1)/PDGFA/PDGFR signaling pathway (Zhu et al., 2022). Here, PDGFA is linked to cancer.