PARP1 and pachyonychia congenita: In addition, oncogenic lncRNAs LINC00346, small nucleolar RNA host gene 8 (SNHG8) and HOST2, have also been shown to confer GEM resistance of PC via regulating the miR-188-3p/BRD4 axis, the caspase-3/PARP axis and apoptosis (Song et al., 2018; Shi et al., 2019; An and Cheng, 2020).