Through enhancer of zeste homolog 2 (EZH2) -mediated epigenetic modification, lncRNA small nucleolar RNA host gene 16 (SNHG16) has been found to confer GEM resistance via diminishing SMAD family member (Smad4) expression in PC (Yu Y et al., 2022). The gene discussed is EZH2; the disease is pachyonychia congenita.