In addition, through suppressing a pro-apoptotic gene of Bcl2-related ovarian killer (BOK) and EMT marker vimentin and N-cadherin, exogenous expression of miR-296-5p has been found to weaken the apoptosis induced by GEM, indicating that targeting miR-296-5p may have therapeutic potential to overcome GEM resistance of PC patients (Okazaki et al., 2020). This evidence concerns the gene BOK and pachyonychia congenita.