Wang et al. demonstrated that S1P acting on S1PR2 induced M1 polarization of intestinal macrophages through the RhoA/ROCK1 pathway in a DSS-induced colitis mouse model (Wang et al., 2022b), revealing that S1P-S1PRs contribute to aggravated intestinal mucosal inflammation by promoting the M1 polarization of macrophages and the production of proinflammatory cytokines. Here, S1PR2 is linked to colitis.