In breast cancer, overexpression of the KHKA isoform induced metastasis through 14-3-3 phosphorylation and recruitment of SLUG to the Cadherin 1 (CDH1) promoter under fructose-fed conditions, suggesting that KHKA, rather than KHKC, is necessary and sufficient for fructose-induced cell invasion.48 Here, SNAI2 is linked to breast carcinoma.