KRAS and neoplasm: Hallmark gene set analyses from all four genotypes showed a significant reduction of cell cycle, inflammation, damage response, metabolism and cell signaling pathways, including Kras and mTORC1 signaling pathways, in tumors of both KPC;KhkC−/− and KPC; KhkA/C−/− mice compared to KPC and KPC;KhkA−/− tumor cells (Figure S5B).