KHK and neoplasm: Inhibition of proliferation was greater in all KHK-mutant genotypes under high fructose conditions, and even KPC;KhkA−/− tumors showed no significant increase in Ki67 stainings compared to KPC control mice fed a high fructose diet, suggesting that under fructose stress both isoforms are required for tumor growth (Figures S4A–S4C).