MUPP and metabolic dysfunction-associated steatohepatitis: Using the MUP-uPA mouse model of NASH-driven HCC, a recent report demonstrated that consumption of a high-fructose diet promoted HCC development through a mechanism involving ER-stress-dependent barrier deterioration in the colon, endotoxemia and deterioration of steatohepatitis through activation of TLR signaling in liver macrophages.17