Alternative splicing of KhkC in the liver is mediated by APOBEC1 complementation factor (A1CF), while heterogeneous nuclear ribonucleoprotein H1/2 (hnRNPH1/2) mediates a c-myc-driven switch of KHKC to the KHKA isoform in dedifferentiated hepatocellular carcinoma (HCC) cells.16 The gene discussed is HNRNPH1; the disease is hepatocellular carcinoma.