In line with these findings, we found that transcriptomics data of Epcam+ CD45− sorted ex vivo cancer cells confirmed the regulation of mTORC1 and KRAS pathways as well as EMT and MYC targets genes, which were impaired in KPC;KhkC−/− compared to KPC;KhkA−/− or KPC tumor cells. The gene discussed is KRAS; the disease is neoplasm.