Surprisingly, in the absence of a high fructose diet we measured higher expression levels of genes involved in pathways related to inflammation, damage response, cell cycle, metabolism, and mTorc1, Kras and Tgfβ signaling in KPC;KhkA−/− compared to KPC alone, KPC;KhkC−/− or KPC;KhkA/C−/− tumor cells. Here, KRAS is linked to neoplasm.