Therefore, ALDH may be applied as a prognostic marker for drug resistance and genetic aberrations. High ALDH activity was found in a subset of human mesenchymal stromal cells with vascular regenerative potential [9], suggesting a preexisting cell capacity for a pro-angiogenic secretory role, which either initiates or mediates the angiogenesis taking place, close to dysplasia or cancer. This evidence concerns the gene LDHA and cancer.