The observation that CD30+ lymphoma B cells in HL, primary mediastinal B-cell lymphoma and a subset of further high-grade lymphomas in nearly all cases carry somatically mutated IGV genes (21–25), indicates that also for CD30+ B cells, a GC passage with the particularly high proliferative activity of GC B cells and the mutagenic processes of somatic hypermutation and class-switching pose a specifically high risk for malignant transformation (26), so that most CD30+ B-cell lymphomas derive from GC-experienced B cells. This evidence concerns the gene TNFRSF8 and Hodgkins lymphoma.