It has been speculated that HRS cells (and perhaps also CD30+ lymphoma cells in B cell Non-Hodgkin lymphomas) may derive from normal CD30+ B cells, and our comparative gene expression profiling study mentioned above indeed revealed that normal CD30+ B cells are the B-cell subset most similar in its gene expression pattern to HRS cells of classical HL, when also considering naive B cells, memory B cells, conventional GC B cells and plasma cells (2). The gene discussed is TNFRSF8; the disease is Hodgkins lymphoma.