PPARGC1A and myeloid sarcoma: Using quantitative polymerase chain reaction (PCR) and western blot, reduced levels of peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1α, a transcriptional coactivator and master regulator of mitochondrial function, were observed with neuronal loss in the cingulate gyrus and frontal cortex of normal appearing gray matter of MS patients, indicating that mitochondria dysfunction could be due partly to PGC-1α (Witte et al., 2013).