NFKB1 and rheumatoid arthritis: The activated NF-κB dimer then binds to target DNA sequences in the nucleus and regulates the transcription of proinflammatory cytokines, growth factors, chemokines, and other target genes, which are important contributors to aggravating the course of RA (Hayden and Ghosh 2008; Taniguchi and Karin 2018).