Furthermore, we constructed an SF‐classifier based on six key splicing factors can accurately predict the clinical outcomes of PCa patients, including BCAS1 (Brain Enriched Myelin Associated Protein 1), LSM3 (LSM3 Homologue, U6 Small Nuclear RNA And MRNA Degradation Associated), DHX16 (DEAH‐Box Helicase 16), NOVA2 (NOVA Alternative Splicing Regulator 2), RBM47 (RNA Binding Motif Protein 47) and SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N). Here, LSM3 is linked to posterior cortical atrophy.