The dysregulation of several key SFs, such as HNRNPL (Heterogeneous Nuclear Ribonucleoprotein L), MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1), SRRM3 (Serine/Arginine Repetitive Matrix 3) and SRRM4 (Serine/Arginine Repetitive Matrix 4), has been shown to contribute to the progression of PCa.11, 12, 13. Here, SRRM4 is linked to posterior cortical atrophy.