A multicenter study on 1,053 in-hospital cardiac arrest and OHCA patients treated with TTM at 32–34 °C reported that the NSE at 72 h had an AUC of 0.85–0.90 and the NSE threshold for poor outcome with FPR 0.5% was > 90 μg/L [17]. This evidence concerns the gene ENO2 and cardiac arrest.