Moreover, FACS analyses demonstrated that the anti-CD98hcECTO-DM1 antibody (hereon referred to as anti-CD98hc-DM1) retained capability to interact with surface-exposed CD98hc present in intact (i) HT29 cells (supplementary Fig. 2C), (ii) cells derived from a PDX grown from a patient with CRC (supplementary Fig. 2D), (iii) cells isolated from a tumoral organoid derived from a patient with CRC (supplementary Fig. 2E). Here, SLC3A2 is linked to colorectal carcinoma.