The remaining 11 patients have TRIF deficiency (n = 1) [19]; warts, hypogammaglobulinemia, infections, myelokathexis syndrome (n = 1) [65]; IRAK4 deficiency (n = 1) [65]; IRF9 deficiency (n = 1) [87]; STAT2 deficiency (n = 1) [132]; interleukin-12 and interleukin-23 receptor b1 chain deficiency (n = 1) [4]; and unspecified innate immunodeficiencies (n = 5) [19, 65, 97, 98]. This evidence concerns the gene IRAK4 and hyperinsulinemic hypoglycemia, familial, 4.