The most frequent main genetic causes of predominantly antibody deficiencies in children infected with SARS-CoV-2 were BTK (n = 41) [8, 19, 34, 40, 46, 49, 50, 52, 63, 65, 71, 73, 74, 85, 91, 92, 95, 97, 105, 117, 120, 129], NFKB2 (n = 4) [27, 36, 95, 122], TNFRSF13B (n = 3) [62, 114, 125], PIK3CD (n = 3) [19, 65, 97], and PIK3R1 (n = 2) [45, 63]. This evidence concerns the gene NFKB2 and agammaglobulinemia.