The most frequent main genetic causes of immune dysregulatory diseases in children infected with SARS-CoV-2 were AIRE (n = 19) [35, 38, 73, 86, 94, 102, 113], LRBA deficiency (n = 6) [57, 58, 115, 125], PRF1 (n = 6) [74, 125], TPP2 (n = 5) [118, 121, 125], LYST (n = 4) [65, 84, 99, 125], XIAP deficiency (n = 4) [43, 65, 95, 100], SH2D1A deficiency (n = 4) [44, 54, 81, 109], STXBP2 (n = 3) [19, 73, 125], UNC13D (n = 2) [19, 125], SOCS1 deficiency (n = 2) [9, 96], CTLA4 deficiency (n = 2) [32, 95], and IL10RA deficiency (n = 2) [74, 125]. This evidence concerns the gene PRF1 and hyperinsulinemic hypoglycemia, familial, 4.