Among them, 8 have TLR7 deficiency (16% of all innate immunodeficiencies) [19, 26, 33, 106, 132], 7 have MyD88 deficiency (14%) [37, 50, 63, 89, 97], 7 have STAT1 deficiency (14%) [52, 65, 68, 73, 95, 125], 3 have IFNAR1 deficiency (6%) [19, 25, 78], 3 have IFNAR2 deficiency (6%) [51], 3 have TYK2 deficiency (6%) [132], 2 have TBK1 deficiency (4%) [10, 114], 2 have isolated congenital asplenia (4%) [81, 108], 2 have IFN-g receptor 2 deficiency (4%) [71, 95], and 2 have MDA5 deficiency (4%) [125]. This evidence concerns the gene TLR7 and hyperinsulinemic hypoglycemia, familial, 4.