The fatality rate was potentially high in children who developed COVID-19 with PAX (2/2 cases), STIM1 (1/2 cases), PIGA (1/2 cases), UNC13D (1/2 cases), CARMIL2 (1/2 cases), TBK1 (1/2 cases), IFNAR1 (2/3 cases), IFNAR2 (2/3 cases), TBCE (2/3 cases), CFH (1/3 cases), IL7Ra (1/3 cases), TNFRSF13B (1/3 cases), SH2D1A (3/4 cases), XIAP (2/4 cases), DNMT3B (1/5 cases), LRBA (1/6 cases), WAS (1/14 cases), AIRE (1/19 cases), and BTK (2/41 cases) deficiencies, although this needs to be confirmed by evaluation of additional pediatric patients with these rare IEIs. The gene discussed is CARMIL2; the disease is COVID-19.