IL6 and dengue disease: For example, elevated levels of IL-6 and IL-8 in cerebrospinal fluid might trigger neurological manifestations and poor outcomes in dengue virus infection [40, 41]; Zika virus is a neurotropic virus transmitted via transplacental transmission from mother to fetus, and after entering the fetus, the virus can infect human neural progenitor cells through the AXL protein receptor, leading to changes in the immune pathway in host cells, which further promotes the appearance of neurological symptoms [42].