A recent study by Liu et al. involved the pathophysiological alterations after the COVID-19 vaccine in which CD8+ T cells reduction, increase in classic monocyte contents, increased NF-κB signaling, and reduced type I interferon responses were reported; they have admitted that in the first 28 days after a vaccine injection, the immune system is in the vulnerable state [109]. The gene discussed is NFKB1; the disease is COVID-19.