Several studies have observed high expression rates of molecules involved in the down-regulation of T-cell activation, Cytotoxic T-lymphocyte antigen-4 (CTLA-4) or Programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1), as well as an expansion of different immunosuppressor cells, as regulatory T cells (Tregs), macrophages associated to tumors and Myeloid-derived suppressor cells (MDSCs) in cervical cancer and their association with malignant transformation and progression [8, 9]. The gene discussed is CD274; the disease is cervical carcinoma.