ESM1 and Sepsis: To be specific, the number of PEVs in patients with sepsis were significantly positively correlated with the levels of serum histone H3 (Pearson’s r = 0.793, P < 0.001), MPO (Pearson’s r = 0.817, P < 0.001), angiopoietin (Pearson’s r = 0.720, P < 0.001) and endocan (Pearson’s r = 0.629, P < 0.001) (Fig. 3A-D).