ESM1 and Sepsis: In brief, compared with normal volunteers, sepsis patients presented significantly elevated levels of histone H3 (4.303 ± 1.516 ng/mL vs. 7.181 ± 1.781 ng/mL, P < 0.01) and MPO (3.545 ± 1.625 ng/L vs. 8.983 ± 2.445 ng/L, P < 0.01) in the serum (Fig. 2A/B) and evidently increased levels of angiopoietin-2 (4512 ± 2284 pg/ml vs. 6552 ± 2220 pg/mL, P < 0.01) and endocan (2158 ± 650.3 pg/mL vs. 3948 ± 494.7 pg/mL, P < 0.01) in the plasma (Fig. 2C/D).