Here, in this paper using blood samples from sepsis patients and controls, we have demonstrated elevated levels of platelet-derived EVs, platelet activation marker (HMGB1), surrogate markers of NET formation (histone H3 and MPO), and endothelial dysfunction and injury (angiopoietin-2 and endocan) in sepsis patients compared to controls. This evidence concerns the gene HMGB1 and Sepsis.