Finally, this phenomenon repressed the activity of both transcription factors, specifically GATA4 and NFAT, and translation factors, namely eukaryotic initiation factor 4E (elf4E) and ribosomal protein S6 kinase (PS6K), which are involved in the development of cardiac hypertrophy (Sundaresan et al. 2009). This evidence concerns the gene RPS6KB1 and cardiac hypertrophy.