IFNA1 and viral infectious disease: Likewise, an introgressed eQTL (rs11119346-T, 43% in East Asians versus less than 3% in Europeans) downregulates TRAF3IP3—a negative regulator of the cytosolic RNA-induced IFN response48—in IAV-infected monocytes, thereby favouring IFN release after viral infection (Extended Data Fig. 9c,d).