Likewise, an approximately 39 kb Neanderthal haplotype, spanning the MUC20 locus in Eurasians, contains the rs2177336-T allele that increases MUC20 expression in SARS-CoV-2-stimulated cells, particularly for CD4+ T cells, and decreases COVID-19 susceptibility (Fig. 6). Here, MUC20 is linked to COVID-19.