Focusing on the PoPH peri-central clusters (Fig. 3a), we then identified signaling pathways (GDF, VCAM, and SEMA7 signaling) uniquely enriched in PoPH peri-central clusters and not present in the other two regions (PoPH peri-portal clusters, non-PoPH cirrhosis peri-central clusters). The gene discussed is PAEP; the disease is Cirrhosis.