GDF2 and Pulmonary arterial hypertension associated with portal hypertension: Plasma levels of BMP9 were also significantly lower in PoPH subjects as compared to non-PoPH cirrhosis in the initial cohort, even after adjustment for age, sex, race/ethnicity, and BMI (logistic regression model AUC of 0.764, 95% CI 0.667–0.861) (Table 3, Fig. 3c, d).