In conclusion, data presented in this study provides evidence that the PoPH liver demonstrates unique patterns of gene expression as compared to the non-PoPH cirrhosis liver, and differential expression of the BMPR2 and ESR1 genes, enhanced signaling through the GDF15 signaling pathway, and enrichment of the arginine biosynthesis pathway are characteristics that are unique to PoPH cells surrounding the central hepatic vein. Here, ESR1 is linked to Cirrhosis.