Using an established GEMM (Ptenflox/flox; Trp53flox/flox; Pbsn-Cre herein referred to as Pten;Trp53pc−/−) we confirmed that conditional loss of Pten and p53 in mouse prostate epithelium results in locally aggressive prostate cancer that is universally fatal. This evidence concerns the gene PTEN and Familial prostate cancer.