Using an established GEMM (Ptenflox/flox; Trp53flox/flox; Pbsn-Cre herein referred to as Pten;Trp53pc−/−) we confirmed that conditional loss of Pten and p53 in mouse prostate epithelium results in locally aggressive prostate cancer that is universally fatal. The gene discussed is TP53; the disease is prostate carcinoma.