TDP2 and Intellectual disability: Mutations in TDP2, encoding tyrosyl-DNA phosphodiesterase 2, have been associated with intellectual disability, cerebellar ataxia, and seizures; a disease known as autosomal recessive spinocerebellar ataxia, type 23 (SCAR23, OMIM #616949) (Gómez-Herreros et al. 2014; Zagnoli-Vieira et al. 2018; Ciaccio et al. 2019; Errichiello et al. 2020; Zoghi et al. 2021).