GJA5 and hereditary elliptocytosis: We integrated GJA5+ AECs into our human EHT ensemble (Supplementary Fig. 7c) and calculated the differentially expressed genes (DEGs) between these two choices (Supplementary Fig. 8c, d; Supplementary Data, pre-HE vs. HE/EC in mouse, C6 vs. V7/GJA5+ AEC), followed by GO term analysis (Fig. 3g, h; Supplementary Data).