To investigate the immune profiles of c-Scorehi tumors across the 25 TCGA tumor types, we evaluated immunomodulatory genes involved in immune checkpoint blockade response, (CD274 [PD-L1], PDCD1 [PD-1], HAVCR2 [TIM3], LAG3, TIGIT, CTLA4, and FASLG). This evidence concerns the gene CD274 and neoplasm.