Across tumor types, these genes were overexpressed in c-Scorehi tumors versus c-Scorelo+med tumors, except for cholangiocarcinoma (CHOL), thymoma (THYM), and kidney papillary renal cell carcinoma (KIRP) that did not meet the false discovery rate (FDR) threshold for CD274, PDCD1, and HAVCR2, respectively (Fig. 2a; Wilcoxon rank-sum, FDR adjusted). Here, CD274 is linked to cholangiocarcinoma.