Interestingly, the propensity of islets to have a negative correlation between RAGE and GCG expression was only present in adolescents from the type 1 diabetes cohort (donors #6228, #6046 and #6195, who were aged 13, 18 and 19 years respectively) and donor #6228—while not an adolescent—had recent history of rapid weight loss and familial hypoglycemia. This evidence concerns the gene AGER and Hypoglycemia.