NOS3 and colorectal cancer: Our team analyzed VEGF and endothelial nitric oxide synthase (eNOS) SNPs in relation to clinical out-come (PFS, OS and overall response rate, ORR) in mCRC patients undergoing Bev-based first-line chemotherapy in the phase III prospective multicenter randomized “Italian Trial in Advanced Colorectal Cancer (ITACa)” study8.