To determine the role of Phlda3 in regulating the development of hematologic malignancies following TBI, we exposed Phlda3+/+, Phlda3+/− and Phlda3−/− littermates to 1.8 Gy TBI every week for 4 consecutive weeks (1.8 Gy × 4). This evidence concerns the gene PHLDA3 and hematologic disorder.