Notably, we found that the ORs for the associations across seven HLA genes, except for HLA-A, were significantly higher for HBV-related cancers than for HCV-related and NBNC cancers (Table 3; e.g., the OR of a DRB1*15:02 allele for HBV-related liver cancer = 1.95, P = 2.8 × 10–5). This evidence concerns the gene HLA-A and cancer.