Previous studies have demonstrated that most SRSFs were extensively dysregulated with oncogenic roles through regulating the AS of various cancer-related genes in many cancers such as lung (SRSF1 [16], SRSF5 [17]), breast (SRSF3 [18]), colon (SRSF1 [19], SRSF10 [20]), liver cancers (SRSF2 [21]), and glioma (SRSF1 [22], SRSF3 [23]). The gene discussed is SRSF1; the disease is liver cancer.