PARP1 and neoplasm: We observed significantly decreased tumor volume and weight in the AMOTL1-L knockdown group compared with the control group (Fig. 5D, E), indicating that depletion of AMOTL1-L inhibited the tumor growth of NPC cells, which was further validated by the reduced Ki-67 (+) cells and induced expression of cleaved-PARP1 in the AMOTL1-L knockdown tumors.