IFNA1 and COVID-19: Recently, it has been shown for SARS-CoV-2 that improper functioning of the IFN system very strongly predisposes individuals to life-threatening COVID-19 (Zhang et al, 2020a, 2020b; Bastard et al, 2020), and we and others have shown that a particularly swift and strong IFN response in children associates with their resilience towards severe courses of the disease (Yoshida et al, 2021; Loske et al, 2022; Magalhães et al, 2023Preprint).