For this purpose, we performed side-by-side 5'ppp-dsRNA stimulation of A549 cells and an unrelated liver (hepatocellular carcinoma) cell line, HepG2, and compared the ensuing mRNA expression (Fig 6A and B), protein abundance and phosphorylation (Fig 6C), and IFN secretion (Fig 6D) dynamics. The gene discussed is IFNA1; the disease is hepatocellular carcinoma.