The key hypoxic regulator HIF-1α, has been shown to be highly expressed in NPC and was a promising involve in cancer cell survival, proliferation, apoptosis, invasion, metastasis etc.13,43,44 To date, although many small molecule HIF-1α inhibitors have emerged, there are no clinically available HIF-1α inhibitors.45–47. This evidence concerns the gene HIF1A and cancer.