Moreover, other signaling molecules such as APC in the Wnt/ β‐catenin signaling pathway have been shown to negatively affect YAP in colon cancer [59], while MST1/2 deletion in the Hippo/YAP pathway was shown to activate β‐catenin in hepatocellular carcinoma [60]. This evidence concerns the gene MST1 and malignant colon neoplasm.