IRF1 and infection: IRF1 regulated PANoptosis in response to infection with Francisella novicida, herpes simplex virus type 1 (HSV1), and IAV and in response to PANoptosis-inducing ligands such as IFN plus KPT-330 or heme plus PAMPs or TNF, and homeostatic disruptions through the inhibition of TAK1 (transforming growth factor-β activating protein kinase 1) with lipopolysaccharide (LPS) priming.